Hotel Accademia is located in Palazzo Sambonifacio Tedeschi, an eighteenth-century building in the heart of the historical center of Verona. In 1750 Architect Adriano Cristofali designed for Giandomenico Tedeschi the revision of the front of the building project that remained unfinished for unknown reasons. Therefore, the monumental facade of the palazzo, hotel since the beginning of the twentieth century, is partly in Renaissance style and partly in eighteenth-century style.

During the World War Two, the bombing of January 4th, 1945, devastated the Hotel Accademia which also occupied the nearby House Giusti on Via Mazzini. From the immediate post-war period until 1956, the owner Onofrio Zenatello commissioned Architect Ettore Fagiuoli to design the reconstruction of the palace facade.

Hotel Accademia is since generations and still today owned by Family Zenatello, whose most illustrious ancestor was Giovanni Zenatello, famous tenor of the late twentieth century, creator, promoter and financier of the Arena opera Festival in Verona.